李俊
点击数:5783 来源:bat365在线平台登录入口 作者: 录入:人员机构 更新时间:2024-10-11
电子邮箱:lijun9593@gxnu.edu.cn
---基本介绍---
博士,二级教授,博士研究生导师,省部共建药用资源化学与药物分子工程国家重点实验室骨干成员。
1989年本科毕业于bat365在线平台登录入口并留校工作,先后在国内的吉林大学、中山大学以及国外的日本富山医科药科大学等多所高校学习。2008年研究生毕业于中山大学有机化学专业,获理学博士学位。2002-2005任资源与环境学系(环境与资源学院前身)副主任、2012-2015任环境与资源学院副院长。
从1992年以来一直从事天然产物的化学成分及其活性、广西特色优势植物资源的深加工与综合利用研究。完成对药用植物罗汉果、银杏叶、鹊肾树、假鹊肾树、青钱柳、红豆杉、八角等成分及其体内和体外抗老年痴呆、抗炎、抗病毒、降血糖、抗肿瘤等活性研究;利用广西特色优势植物资源罗汉果、银杏叶等,成功开发了系列产品。主持完成22项科研课题的研究,其中主持国家自然科学基金资助课题3项、广西重点自然基金项目3项、广西省自然基金面上项目3项、广西科技攻关项目1项、教育部重点项目1项。主持的“食品添加剂罗汉果甜甙的研制”、“银杏叶提取黄酮工艺研究与应用开发”项目成果应用于生产后,实现三年总销售额3015万元,税利1020多万元;转让的专利项目“舒血宁注射液脱酸纯化关键技术开发及应用” 实现转化当年销售额超1亿元,取得良好的经济效益和社会效益。2016年获省级科技进步一等奖1项、2015年获省级自然科学进步三等奖1项、1996年获省级科技进步三等奖2项;在Bioorg Chem、J Agric Food Chem、Chem Commun、J Nat Prod、Phytochemistry、JEthnopharmacol、Bioorg Med Chem Lett、Planta Med和中草药等国内外刊物上发表科技论文100多篇;担任Bioorg Chem、J Agric Food Chem、Chem Commun、J Nat Prod、Phytochemistry、JEthnopharmacol等期刊的审稿人;获得国家发明专利14项;已经培养博士研究生、硕士研究生50余名。
---研究方向---
天然产物的化学成分、活性及其作用机制,广西特色优势植物资源的深加工与综合利用研究。
---代表性论文---
[1] Yan Huang, Ping Hou, Liwei Pan, Xiaoqin Liang, Chenyang Ren,Liuting Peng, Chunqiu Gan, Ruiyun Yang, Weifeng Xu, Jun Li*, Yanjun Zhang.Oleanane-type triterpenoids from Sabialimoniacea and their anti-inflammatory activities. Bioorganic Chemistry, 2024,151: 107683.
[2] Yan Huang,Liwei Pan, Yanling Chang, Xiaoqing Liang, Ping Hou, Chenyang Ren, Weifeng Xu,Ruiyun Yang, Jun Li, Buming Liu. Megastigmane glycosides from Streblusilicifolius (S.Vidal) Corner and their anti-inflammatory activity. Phytochemistry,2023, 208:113606.
[3] Xiaoqing Liang,Shengping Deng, Yan Huang, Liwei Pan, Yanling Chang, Ping Hou, Chenyang Ren,Weifeng Xu, Ruiyun Yang, Kanyuan Li, Jun Li*, Ruijie He.Triterpenoids from the leaves of Cyclocarya paliurus and their glucoseuptake activity in 3T3-L1 adipocytes. Molecules, 2023, 28 (8):3294-3309.
[4] Rehab MobarkOsman Mohammed, Yan Huang, Xinlan Guan, Xishan Huang, Shengping Deng, RuiyunYang, Jian Li*, Jun Li*.Cytotoxic cardiac glycosides from the root of Streblus asper. Phytochemistry, 2022, 200: 113239/1-113239/11.
[5] Chenguo Li,Shengping Deng, Wei Liu, Dexiong Zhou, Yan Huang, Lili Hao, Gaorong Zhang,Shanshan Su, Xia Xu, Ruiyun Yang, Chengqin Liang, Xishan Huang*, Jun Li*.α-Glucosidase inhibitory and anti-inflammatory activities of dammarane triterpenoids from the leaves of Cyclocarya paliurus. Bioorganic Chemistry, 2021, 111:104847/1-104847/13.
[6] Wei Liu,Shengping Deng, Dexiong Zhou, Yan Huang, Chenguo Li, Lili Hao, Gaorong Zhang,Shanshan Su, Xia Xu, Ruiyun Yang, Jun Li*, Xishan Huang*. 3,4-seco-Dammarane triterpenoid saponins with anti-inflammatoryactivity isolated from the leaves of Cyclocarya paliurus. Journal of Agricultural and Food Chemistry, 2020, 68 (7):2041-2053.
[7] Ruijie He, XishanHuang, Yanjun Zhang, Liangdeng Wu, Hui Nie, Dexiong Zhou, Buming Liu, ShengpingDeng, Ruiyun Yang, Shuai Huang, Zhijie Nong, Jun Li*, Yan Huang*. Structural characterization and assessment of thecytotoxicity of 2,3-dihydro-1-H-indene derivatives and coumarin glucosides fromthe bark of Streblus indicus. Journal ofNatural Products, 2016, 79 (10): 2472-2478.
[8]Yanjun Zhang, XishanHuang, Huangcan Chen, Dexiong Zhou, Zhengmin Yang, Ke Wang, Wei Liu, ShengpingDeng, Ruiyun Yang, Jun Li*, Ruijie He*. Discovery ofanti-inflammatory terpenoids from Mallotusconspurcatuscroizat. Journal of Ethnopharmacology, 2019,231(1): 170-178.
[9] YanjunZhang, Ke Wang, Huangcan Chen, Ruijie He, Runlin Cai, Jian Li, Dexiong Zhou,Wei Liu, Xishan Huang, Ruiyun Yang, Shengping Deng, Jun Li*, Xinlan Guan*.Anti-inflammatory lignans and phenylethanoid glycosides from the root of Isodonternifolius (D.Don) Kudo. Phytochemistry, 2018, 153 (9): 36-47.
[10] ZhengminYang, QingyuanMo, Jiman He,Jun Li*, Hua Chen, Shulin Zhao, JiangkeQin*. Mitochondrial-targeted andnear-infrared fluorescence probe for bioimaging and evaluating monoamineoxidase a activity in hepatic fibrosis.ACS Sensors, 2020, 5(4):943-951.
[11] Zhengmin Yang, Wenxiu Li, Hua Chen,Qingyuan Mo, Jun Li*, Shulin Zhao, Cheng Hou, Jiangke Qin*, Guifa Sua. Inhibitor structure-guided design and synthesis of near-infraredfluorescent probes for monoamine oxidase A (MAO-A) and its application inliving cells and in vivo. Chemical Communications,2019, 55 (17): 2477-2480.
[12]Dexiong Zhou, Xishan Huang, Wei Liu, Yan Huang, Ruiyun Yang, Shengping Deng*, Jun Li*. Bioactivity-guided isolationof anti-inflammatory constituents from the bark of Streblus zeylanicus. Fitoterapia,2020, 147: 104770/1-104770/8.
[13] Yanjun Zhang,Dexiong Zhou, Wei Liu, Chenguo Li, Lili Hao, Gaorong Zhang, Shengping Deng,Ruiyun Yang, Jiangke Qin, Jun Li*. Cytotoxicactivity and related mechanisms of prenylflavonoids isolated from Mallotusconspurcatus CROIZAT. Chemistry & biodiversity, 2019, 16 (5):e1800465.
[14] RuijieHe, Yanjun Zhang, Liangdeng Wu, Hui Nie, Yan Huang, Buming Liu, Shengping Deng,Ruiyun Yang, Shuai Huang, Zhijie Nong, Jun Li*, Haiyan Chen*. Benzofuranglycosides and coumarins from the bark of Streblus indicus (Bur.)Corner. Phytochemistry, 2017, 138 (6): 170-177.
[15] Jun Li*, Yan Huang, Xinlan Guan, Jian Li, ShengpingDeng, Qiang Wu, Yanyun Zhang, Xiaojian Su, Ruiyun Yang. Anti-hepatitisB virus constituents from the stem bark of Streblusasper. Phytochemistry,2012, 82 (10): 100-109.
[16] Jun Li*, Aiping Meng, Xinlan Guan, JianLi, Qiang Wu, Shengping Deng, Xiaojian Su, Ruiyun Yang. Anti-hepatitisB virus lignans from the root of Streblusasper. Bioorganic & Medicinal ChemistryLetters, 2013, 23 (7): 2238-2244.
[17] Chen Li,Cuiping Huang, Tailiang Lu, Liangdeng Wu, Shengping Deng, Ruiyun Yang, JunLi*. Tandem mass spectrometric fragmentation behaviorof lignans, flavonoids and triterpenoids in Streblus asper. RapidCommunications in Mass Spectrometry, 2014, 28 (21): 2363-2370.
[18] Luqing Li, Jun Li*, Yan Huang, Qiang Wu, ShengpingDeng, Xiaojian Su, Ruiyun Yang, Jiguo Huang, Zizhan Chen, Shan Li. Lignans fromthe heartwood of Streblus asper and their inhibitingactivities to hepatitis B virus. Fitoterapia,2012, 83 (2): 303-309.
[19] HongChen, Jun Li*, Qiang Wu, Xiaotao Niu, MaotongTang, Xinlan Guan, Jian Li, Ruiyun Yang, Shengping Deng, Xiaojian Su.Anti-HBV activities of Streblus asper and constituents of itsroots. Fitoterapia, 2012, 83 (4):643-649.
[20] Shan Li, Jian Li, Xinlan Guan, Jun Li*, Shengping Deng, Luqing Li,Maotong Tang, Jiguo Huang, Zizhan Chen, Ruiyun Yang. Hypoglycemic effects andconstituents of the barks of Cyclocarya paliurus and theirinhibiting activities to glucosidase and glycogen phosphorylase. Fitoterapia, 2011, 82 (4): 1081-1085.
[21] Jun Li*,Maotong Tang, Qiang Wu, Hong Chen, Xiaotao Niu, Xinlan Guan, Jian Li, ShengpingDeng, Xiaojian Su, Ruiyun Yang. Water-soluble constituents of the heartwood of Streblus asper. NaturalProduct Communications, 2012, 7 (5): 599-602.
[22] Jun Li *, Fu Li, Yuanyuan Lu, XiaojianSu, Cuiping Huang, Xuewen Lu. A new dilactone from the seeds of Gaultheriayunnanensis. Fitoterapia, 2010, 81 (3):35-37.
[23] Jun Li, Yuanyuan Lu, Xiaojian Su, FuLi, Zhigang She*, Xingcun He, Yongcheng Lin*. A norsesquiterpene lactone, abenzoic acid derivative from leaves of Cyclocaryapaliurus (Batal.) Iljinsk and their activities inhibiting glucosidaseand glycogen phosphorylase. PlantaMedica, 2008, 74 (3): 287-289.
[24] Jun Li, Yanjun Zhang, Baifeng Jin,Xiaojian Su, Yiwen Tao, Zhigang She*, Yongcheng Lin*. 1 H and13 C NMR assignments for two lignans from heartwood of Streblus asper. MagneticResonance in Chemistry, 2008, 46 (5): 497-500.
[25] Tailiang Lu, Shengping Deng, Chen Li, Liangdeng Wu, Ruiyun Yang, JunLi*. A new chromone from the twig of Mallotus apelta. Natural Product Research, 2014, 28 (21): 1864-1868.
[26] Liangdeng Wu, Chunlan Xiong,Zizhan Chen, Ruijie He, Yanjun Zhang, Yan Huang, Shengping Deng*, Ruiyun Yang,Jun Li*. A new flavane acid from the fruits of Illicium verum. Natural Product Research, 2016, 30 (14): 1585-1590.
[27] Hui Nie, Xinlan Guan**, Jian Li,Yanjun Zhang, Ruijie He, Yan Huang, Buming Liu, Dexiong Zhou, Shengping Deng,Huangcan Chen, Ruiyun Yang, Jun Li*. Antimicrobial lignans derived fromthe roots of Streblus asper. Phytochemistry Letters, 2016, 18(4): 226-231.
[28] Ruijie He, Shengping Deng, Hui Nie,Yan Huang, Buming Liu, Ruiyun Yang, Shuai Huang, Dexiong Zhou, Huangcan Chen, JunLi*, Yanjun Zhang*. Two newcoumarins from the bark of Streblus indicus (Bur.) Corner. NaturalProduct Research, 2017, 31 (9): 1052-1058.
[29]Gaorong Zhang, Lili Hao, Dexiong Zhou, Wei Liu, Chenguo Li, Shanshan Su, XiaXu, Xishan Huang*, Jun Li*. A newphenylpropanoid glycoside from the bark of Streblusilicifolius (Vidal) Corner. BiochemicalSystematics and Ecology, 2019, 87:103962/1-103962/5.
---主持的主要科研项目---
1、国家自然基金项目,基于Akt-IκB-NF-κB级联反应和MAPK通路研究野桐属三种药用植物抗炎萜类及其作用机制(32060097),2021/01-2024/12,在研,主持。
2、国家自然基金项目,三种鹊肾树属植物抗HBV苯丙素的发现及其构效关系和作用机制(21662004),2017/01-2020/12,结题,主持。
3、国家自然基金项目,广西民族中药鹊肾树化学成分及其活性研究(国家自然科学基金 20862002),2009/01-2011/12,结题,主持。
4、广西壮族自治区自然基金重点项目,香茶菜属瑶药中抗HBV二萜和三萜的发现和作用机制研究(2018GXNSFDA050007),2019/01-2022/12,结题,主持。
5、广西壮族自治区自然基金重点项目,壮药假鹊肾树化学成分及其抗乙肝病毒和抗肿瘤活性研究(2014GXNSFDA118008),2014/06-2017/06,结题,主持。
6、广西壮族自治区自然基金重点项目,广西民族中药鹊肾树化学成分的筛选和开发(桂科基 0832005),2008/06-2011/05,结题,主持。
7、广西壮族自治区科技攻关项目,膜分离技术对青钱柳降血糖活性成分的提取与分离及其产品的开发(桂科能051121-3),2005/06-2008/05,结题,主持。
8、药用资源化学与药物分子工程教育部重点实验室团队项目,广西道地民族药药效物质基础及其药理研究(CMEMR2012-A21),2013/06-2016/05,结题,主持。
9、教育部创新团队项目,天然活性物质的发现结构改选与功能(子课题,F-2911-15-000008),2015/06-2017/05,结题,主持。
10、广西壮族自治区自然基金项目,罗汉果中多糖的提取分离和性质研究(桂科基0575043),2005/06-2008/05,结题,主持。
11、广西自然基金项目,满山香子中活性成分的筛选及膜分离研究(桂科自0339032),2003/06-2006/05,结题,主持。
12、教育部重点项目,中药抗老年痴呆活性成分的分离筛选研究(教育部重点项目No.0194),2001/06-2004/05,结题,主持。
13、广西壮族自治区自然基金项目,广西主产中草药抗老年痴呆药物的筛选分离研究(桂科基0144025),2001/06-2004/05,结题,主持。
14、广西中药质量标准研究重点实验室项目,假鹊肾树化学成分及其抗肿瘤活性研究(桂中重开201405),2014/06-2016/05,结题,主持。
15、广西壮族自治区人才小高地项目,八角果实中新化合物的发现及其抗肿瘤活性研究(广医人高[2012] 1202),2012/06-2014/05,结题,主持。
16、863 国家高新技术研究发展计划项目,海洋生物资源的开发利用技术-抗结核菌活性海洋微生物代谢产物筛选和开发(2007AA09Z414),2007/06-2010/05,结题,参与。
17、国家自然基金,南海几种药用红树共生微生物活性代谢产物研究(20772498),2008/01-2010/12,结题,参与。
18、国家自然基金,花生蛋白油脂乳状液的形成及其胶体化学性质的研究(29160009),1992/01-1994/12,结题,参与。
19、国际合作项目,罗汉果有效成分的研究与开发(国际合作课题),2015/06-2017/05,结题,参与。
20、广西壮族自治区自然基金项目,灵香草水溶性部分的有效化学成分和药理活性研究(桂科基0731050),2007/06-2010/05,结题,参与。
21、广西壮族自治区自然基金项目,大蚝抗癌活性成分的分离及其产品开发(桂科自0832281),2008/06-2011/05,结题,参与。
---科研奖励---
1、四种广西特色植物的化学成分、生物活性及其开发利用研究(广西自然科学进步三等奖, 排名第一, 2015)。
2、舒血宁注射液脱酸纯化关键技术开发及应用(山西科技进步一等奖, 排名第七, 2016)。
3、食品添加剂罗汉果甜甙的研制(广西科技进步三等奖, 排名第一, 1996)。
4、银杏叶提取黄酮工艺研究与应用开发(广西科技进步三等奖, 排名第五, 1996)。