胡坤 [研究员]

联系方式

办公电话：0773-2535678

手机号码：18178702026

电子邮箱：hukun216@mailbox.gxnu.edu.cn; hukun216@163.com

办公地址：药用资源化学与药物分子工程国家重点实验室103室

基本介绍

胡坤，男，安徽宿州人，理学博士，研究员职称，博士生导师。主要从事样品前处理、质谱分析及生物传感器等方面的研究工作。曾主持各类科研课题十余项，其中国家自然科学基金项目2项，省部级科研项目2项。 已在Anal.Chem;Chem.Commun；Biosensors and  Bioelectronics；Analyst；Microchimica Acta等国内外学术期刊发表SCI学术论文十余篇。Analytical Chemistry; Biosensors and Bioelectronics；ACS Nano; Analytical Methods等期刊审稿人。

研究方向

1. 质谱分析

2. 样品前处理

3. 生物传感器

学历背景

工作经历

论著专利

[1] Kun Hu, Yuanxia Lv, Fanggui Ye,* Tao Chen, and Shulin Zhao*，Boric-Acid-Functionalized Covalent Organic Framework for SpecificEnrichment and Direct Detection of cis-Diol-Containing Compoundsby Matrix-Assisted Laser Desorption/Ionization Time-of-Flight MassSpectrometry，Anal. Chem. 2019, 91, 6353-6362.

[2]Yuanxia Lv, Xiaohuan Qin, Kun Hu*, Fanggui Ye, ShulinZhao*, Microporous hydrogen-bond organic frameworks-based SALDI-TOF MS for simultaneous enrichment and high sensitivity detection of paraquat and chlormequat, Sensors and Actuators: B. Chemical., Accepted.

[3] Yuanxia Lv, Xiaohuan Qin, Kun Hu*, Yong Huang, Shulin Zhao, Hybrid MoS2/g-C3N4-assisted LDI mass spectrometry for rapiddetection of small molecules and polyethylene glycols and directdetermination of uric acid in complicated biological samples, Microchimica Acta (2021) 188: 5.

[4] Jiayao Xu, Ming Shi, Huakui Huang, Kun Hu,* Wenting Chen,Yong Huang,* Shulin Zhao, A fluorescent aptasensor based on single oligonucleotide-mediated isothermal quadratic amplification and graphene oxide fluorescence quenching for ultrasensitive protein detection, Analyst, 2018, 143, 3918-3925.

[5]Yuanxia Lv, Caiyan Jiang, Kun Hu*, Yong Huang, Yunfeng He, Xiaoying Shen, Shulin Zhao*,  In-situ growth of cobalt oxyhydroxide on graphitic-phase C3N4nanosheets for fluorescence turn-on detection and imagingof ascorbic acid in living cells, Microchimica Acta (2019) 186: 360.

[6] Kun Hu, * Chensi Liu, Jingui Li, Fupei Liang, CopperIJII) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer, Med. Chem. Commun., 2018, 9, 1663-1672.

[7] Kun Hu,* Jinwen Liu, Jia Chen, Yong Huang, Shulin Zhao*, Jianniao Tian, Guohai Zhang, An amplified graphene oxide-based fluorescence aptasensor based on target-triggered aptamer hairpin switch and strand-displacement polymerization recycling for bioassays , Biosensors and Bioelectronics, 2013, 42(6): 598-602.

[8] Kun Hu*, Yong Huang, Sheng’e Wang, Shulin Zhao*, A carbon nanotubes based fluorescent aptasensor for highly sensitive detection of adenosine deaminase activity and inhibitor screening in natural extracts , Journal of Pharmaceutical and Biomedical Analysis, 2014, 95: 164-168.

[9] Kun Hu*, Tianmei Zhong, Yong Huang, Zhenfeng Chen, Shulin Zhao*, Graphitic carbon nitride nanosheet-based multicolour fluorescentnanoprobe for multiplexed analysis of DNA, Microchim Acta, 2014, 182(5): 949-955.

[10] Kun Hu, Feiyan Li, Zhong Zhang, Fupei Liang*, Synthesis of two potential anticancer copper(II) complex drugs: their crystal structure, human serum albumin/DNA binding and anticancer mechanism, New Journal of Chemistry, 2017, 41: 2062-2072.

[11] Kun Hu, Guimei Zhou, Zhong Zhang, Feiyan Li, Jingui Li, Fupei Liang*, Two hydrazone copper(II) complexes: synthesis, crystal structure, cytotoxicity, and action mechanism, RSC Advances, 2016, 6(42): 36077-36084.

[12] Huakui Huang, Jian Qin, Kun Hu*, Xiaoqian Liu, Shulin Zhao, Yong Huang*, Novel autonomous protein-encoded aptamer nanomachines and isothermal exponential amplification for ultrasensitive fluorescence polarization sensing of small molecules, RSC Advances, 2016, 6(89): 86043-86050.

[13] Kun Hu,* Yong Huang, Shulin Zhao,* Jianniao Tian, Qiang Wu, Guohai Zhang and Jing Jiang, Ultrasensitive detection of potassium ions based on target induced DNA conformational switch enhanced fluorescence polarization, Analyst, 2012, 137, 2770-2773.

科研项目

1. 国家自然科学基金，基于聚β-环糊精主客体策略和核酸等温信号放大技术增强荧光偏振分析新技术及用于病原体多元检测，主持，已结题。

2.国家自然科学基金，基于表面分子印迹MALDI质谱技术的复杂体系中抗生素检测新方法研究，主持，在研。