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谭艳辉

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谭艳辉 博士,副教授,执业药师,健康管理师,硕士生导师

电子邮箱:tyh533@126.com 办公地址:国家重点实验室2号楼201

 

基本介绍

主要从事天然小分子化合物对骨破坏相关疾病的治疗作用以及炎症与免疫在骨破坏疾病发生发展中的分子机制研究。目前主持国家自然科学基金青年项目1项,广西自然科学基金面上项目、青年项目各1项,获资助在研研究项目合计6项。申请发明专利6项,获得授权4项,目前以第一作者或通讯作者在British Journal of Pharmacology、Journal of Medicinal Chemistry、Biochemical Pharmacology、Cell Death & Disease、Journal of Advanced Research、European Journal of Medicinal Chemistry、Journal of Natural Products等主流期刊发表学术论文20篇。国家自然科学基金医学部通讯评审专家。

 

教育背景

2016.09-2019.06 南方医科大学 药理学 博士

2007.09-2009.06 武汉大学 免疫学 硕士

2002.09-2006.06 郑州大学 药学 学士

  

工作经历

2022.12-至今 bat365在线平台登录入口 bat365在线平台登录入口 副教授

2019.10-2022.11 bat365在线平台登录入口 bat365在线平台登录入口 讲师

2010.09-2016.08 湖南医药学院 药学院 讲师


讲授课程

药理学,临床药物治疗学,高级生物化学


荣誉及奖励

1、2020.07 获全区第七届高校青年教师教学竞赛医科组三等奖

2、2020.06 获bat365在线平台登录入口青年教师教学竞赛二等奖

3、2015.06 获湖南省高校青年教师教学竞赛三等奖

 

科研项目

1. 国家自然科学基金青年科学基金项目(主持,82104496)

2. 广西自然科学基金面上科学基金项目(主持,2023GXNSFAA026441)

3. 广西自然科学基金青年科学基金项目(主持,2021GXNSFBA196068)

4. 广西中青年科研基础能力提升项目(主持,2021KY0062)

5. 省部共建药用资源化学与药物分子工程国家重点实验室人才引进项目(主持,CMEMR2019-A05)


代表性论著

(1)Zhi-chao Li#, Min Li#, Ling-xiang Xiao, Xi Zheng, Rong Li, Shi-jia Dong, Yue Wang, Hong-yu Wen, Kun-lin Ruan, Ke-guang Cheng*, Ming Chen* and Yanhui Tan*.6-o-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-src/nf-κb/nfatc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model. Biochemical Pharmacology. 2024 Apr 19:116230. (IF: 5.8,医学2区)

(2)Jiehuang Zheng#, Weili He#, Yan Chen#, Lihong Li, Qinghe Liang, Wenqi Dai, Ruopeng Li, Fengsheng Chen, Ziye Chen, Yanhui Tan*, Xiaojuan Li*. Erianin serves as an NFATc1 inhibitor to prevent breast cancer-induced osteoclastogenesis and bone destruction. Journal of Advanced Research. 2024 Mar 30:S2090-1232(24)00121-8. (IF: 10.7,综合1区)

(3)Chen C#, Xiao L#, Luo X#, Cai J, Huang L, Tao H, Zhou X*, Tan Y*, Liu Y*. Identifying Marine-Derived Tanzawaic Acid Derivatives as Novel Inhibitors against Osteoclastogenesis and Osteoporosis via Downregulation of NF-κB and NFATc1 Activation. J Med Chem. 2024 Feb 22;67(4):2602-2618.(IF: 7.3,医学1区)

(4)Jian Cai#, Min Li#, Chunmei Chen#, Bin Yang, Chenghai Gao,Yonghong Liu, Xiaowei Luo*, Yanhui Tan*,and Xuefeng Zhou*. PeniditerpenoidsA and B: Oxidized Indole Diterpenoids with Osteoclast Differentiation Inhibitory Activity from a Mangrove- Sediment-Derived Penicillium sp. Journal of Natural Products. 2024, https://doi.org/10.1021/acs.jnatprod.4c00116 (IF:5.1, 生物学2区)

(5)Jing Wang, Yun Song, Ziying Huang, Wenjing Lin, Guangying Yu,Yanshi Xiong, Guijuan Jiang, Yanhui Tan*,Jintao Wang*, Xiangwen Liao*.Coupling a Virulence-Targeting Moiety with Ru-Based AMP Mimics Efficiently Improved Its Anti-Infective Potency and Therapeutic Index. J Med Chem. 2023 Sep 28;66(18):13304-13318. (IF: 7.3,医学1区)

(6)Shuang Kan#; Rong Li#; Yanhui Tan#; FangYang; Shaohua Xu; Lingzhu Wang; Lijun Zhang; Xuchen Sun; Xuanming Chen; Yuting Yang; Wei Shu; Huaibin Wan; Zheng-Feng Chen; Hong Liang* and Ming Chen*; Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet. Cell Death &Disease. 2022, 24, 13(2): 175. doi: 10.1038/s41419-022-04636-9. (IF:8.882, 生物学1区)

(7)Yanhui Tan#; Minhong Ke#; Zhichao Li; Yan Chen; Jiehuang Zheng; Yiyuan Wang; Xuefeng Zhou*; Gang Huang*; Xiaojuan Li*; A Nitrobenzoyl Sesquiterpenoid Insulicolide A prevents osteoclast formation via suppressing c-Fos-NFATc1 signaling pathway. Frontiers in Pharmacology. 2022,Jan 17, 12:753240. (IF:5.81,医学2区)

(8)Cai J#, Gao L#, Wang Y#, Zheng Y, Lin X, Zhou P, Chen C, Liu K,Tang L, Liu Y, Tan Y*, Jin M*, ZhouX*. Discovery of a novel anti-osteoporotic agent from marine fungus-derived structurally diverse sirenins. Eur J Med Chem. 2024 Feb 5;265:116068.(IF: 6.7,医学1区)

(9)Yanting Zhang#; Zhichao Li#; Bingyao Huang; Kai Liu; Shuai Peng; Xinming Liu; Chenghai Gao; Yonghong Liu*; YanhuiTan* and Xiaowei Luo*; Anti-Osteoclastogenic and Antibacterial Effects of Chlorinated Polyketides from the Beibu Gulf Coral-Derived Fungus Aspergillus unguis GXIMD 02505. Marine Drugs. 2022, 20, 178. doi.org/10.3390/ md20030178. (IF:5.4,医学2区)

(10)Yanhui Tan#; Wende Deng#; YueyangZhang; Minhong Ke; Binhua Zou; Xiaowei Luo; Jianbin Su; Yiyuan Wang; Jialan Xu; Kutty Selva Nandakumar; Yonghong Liu; Xuefeng Zhou *; Xiaojuan Li *; A marine fungus-derived nitrobenzoyl sesquiterpenoid suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and inflammatory bone destruction. British Journal of Pharmacology. 2020, 177: 4242-4260. (IF:8.739, 药学1区)

(11)Yanhui Tan#; Bin Yang#; Xiuping Lin; Xiaowei Luo; Xiaoyan Pang; Lan Tang; Yonghong Liu; Xiaojuan Li*; Xuefeng Zhou*; Nitrobenzoyl sesquiterpenoids with cytotoxic activities from a marine-derived Aspergillus ochraceus fungus. Journal of Natural Products. 2018, 81(1): 92-97. (IF:5.1, 生物学2区)


其他

欢迎对生物医药,化学生物学感兴趣的同学报考本实验室硕士研究生,欢迎本科生同学到实验室进行生物医学专业训练。