Contact Information

Position: Researcher

Tel: 0773-2120958

Email: pengyan630@aliyun.com

Address:

Introduction

      In July 2004, Shanghai Second Military Medical University graduated in biochemistry and molecular biology with a doctorate in medicine. Engaged in synthetic drug chemistry and pharmacology ( anti - tumor, anti - fibrosis ) research. Presided over 1 top-level project of the National Natural Science Foundation, 1 sub-project of the National 973 Project, 1 key project of Guangxi Natural Science Foundation and 1 top-level project. Published more than 40 papers in J. Bio. Chem, J. Med. Chem, Eur. J. Med. Chem, Biochem. Pharmacol and other domestic and foreign publications. Six national invention patents were granted.

Areas of Research Interests

1. Tumor pharmacology

2. Biochemistry and molecular biology

Education background

Work Experiences

Academic Achievement

[1]Xing Lu, YiMing Wu , JingMei Yang , FengE. Ma , LiangPing Li , Sheng Chen ,Ye Zhang , QingLing Ni , YingMing Pan , Xue Hong* , Yan Peng *. Preparation of Rhodium(III) complexes with 2(1H)-quinolinone derivatives and evaluationof their in vitro and in vivo  antitumor activity. European Journal of Medicinal Chemistry,2018:151:226-236

[2]JingMei Yang, YanHong Zhu, Sheng Chen, Xing Lu, YiMing Wu, FengE Ma, LiangPing Li, Yang Yang, ZhenHao Shi, KunYuan Huang, Xue Hong, Ping Jiang*, Yan Peng*A β-carboline derivative-based nickel(II) complex as a potential antitumor agent: synthesis,characterization, and cytotoxicity.Med Chem Commun, 2018;9:100-107

[3]Guohai Zhang, Yunfeng An, Xing Lu, Hui Zhong, Yanhong Zhu, Yiming Wu, Fenge Ma, Jingmei Yang, Yancheng Liu, Zuping Zhou, Yan Peng*, Zhen-Feng Chen*. A Novel Naphthalimide Compound restores p53 function in Non–Small–Cell Lung Cancer by Reorganizing the Bak–Bcl-xl Complex and Triggering Transcriptional Regulation. J. Bio. Chem.2016, 291(8), 4211-4225

[4]Zhen -Feng Chen,*Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li, Ting Meng, Guo-Hai Zhang, Yan Peng, Xu-Jian Luo, and Hong Liang* .Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Tumor Cell Apoptosis by Organoplatinum(II) Complexes with Oxoisoaporphine. J. Med. Chem.2015, 58(5), 2159-2179

[5]Yan Wang,Yan Peng*, Yingqiong Zhou, Yuanhua Zhou, Hui Zhong. The Clinical Value of LRRC3B Gene Expression and Promoter Hypermethylation in Breast Carcinomas. Cell Biochem Biophys, 2014. 70(2),1035-1041.

[6]Ye Zhang, Yilin Fang, Hong Liang, Hengshan Wang, Kun Hu, Xianxian Liu, Xianghui Yi*, Yan Peng*. Synthesis and antioxidant activities of 2-oxo-quinoline-3-carbaldehyde Schiff-base derivatives. Bioorganic & Medicinal Chemistry Letters, 44(20), 107-111, 2013.

[7]Guohai Zhang, Lejing Cai, Yanfei Wang, Yuanhua Zhou, Yunfeng An, Yancheng Liu, Yan Peng*, Zhenfeng Chen*, Hong Liang*. Novel compound PS-101 exhibits selective inhibition in non–small-cell lung cancer cell by blocking the EGFR-driven antiapoptotic pathway. Biochem. Pharmacol., 86(12): 1721-1730, 2013

Research Projects

1. The Role of P53 Phosphorylation Sites S15 and S392 in Reconstructing p53 Function in Non - small Cell Lung Cancer and the Intervention Mechanism of Naphthalimide Compounds

2. Synthesis, Antitumor Activity and Molecular Mechanism of Heterologous Multi - target β-carboline Alkaloid Metal Complexes