Contact Information

Position: Professor

Tel: +86-13977309866

Email: hyhth@163.com

Address:

Academic Achievement

[1] Wei, Shenqi,Chen, Wei, Qin, Jingfang, Huangli, Yingzi, Wang, Li, Shen, Yue, Tang, Huang*, Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer’s disease. Bioorg. Med. Chem.2016, 24(22): 6031-6039.

[2] HAI-TAO ZHAO, SHU-MING ZHONG, JIANG-KE QIN and Huang Tang*. Novel Hybrids of Oxoisoaporphine-Tryptamine as Acetylcholinesterase-induced β-amyloid Aggregation Inhibitors, with Improved Antioxidant Properties. J. Ser. Chem. Soc. 2015, 80 (2) 127–136.

[3] Wei Chena, Yuhuan Wub, Shuming Zhongb, Ling Chenga, Qinghua Li, Huang Tang*. Anti-neurotoxicity effects of oxoisoaporphine-lipoic acid hybrids. Chem-Biol. Interact.  2014, 223(5): 45–50.

[4] Zhong, Shuming; Wei, Shenqi; Liu, Yun; Tang, Huang*. Synthesis and Biological Evaluation of 6-[(Alkylamino) hydrazide-yl]-1-azabenzanthrone Derivatives. Chin. J. Org. Chem. 2014, 1: 137-146.

[5] Tang Huang ,  Hao-Tao Zhao, Shu-Ming Zhong, Zhi-Yu Wang, Zhen-Fen Chen. Novel Oxoisoaporphine-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced beta-Amyloid Aggregation. Bioorg. Med. Chem. Lett. 2012,22：2257-2261.

[6] Tang Huang; Zhao, L.-Z.; Zhao, H.-T.; Huang, S.-L.; Zhong, S.-M.; Qin, J.-K.; Chen, Z.-F.; Huang, Z.-S.; Liang, H., Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase-induced beta -amyloid aggregation inhibitors. Eur. J. Med. Chem. 2011, 46, (10), 4970-4979.

[7] Tang. Huang, Y.Biao Wei, Chi Zhang, Fang-Xian Ning, Wei Qiao , Shi-Liang Huang, Lin M, Zhi-Shu Huang, Lian-Quan Gu.  Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase." Eur. J. Med. Chem. 2009, 44(6), 2523-2532.

[8] Huang Tang, F-X. Ning, Y-B. Wei, S-L. Huang, Z-S. Huang, A.S-C. Chan, L-Q. Gu. Derivatives of Oxoisoaporphine Alkaloids: A novel class of selective acetylcholinesterase inhibitors, Bioorg. Med. Chem. Lett. 2007, 17(13), 3765-3768.

[9] Tang Huang, X.Dong Wang, Y.Biao Wei, S.Liang Huang, Z.Shu Huang, J.Heng Tan, L.Kun An, J.Yong Wu, A. Sun-Chi Chan, L.Quan Gu. Oxoisoaporphine Alkaloid Derivatives: Synthesis, DNA Binding Affinity and Cytotoxicity, Eur. J. Med. Chem. 2008,  43, 973-980.