Contact Information

Position:Professor

Tel:

Email: chenmingprotein@163.com

Address:

Website: http://www.escience.cn/people/ChenLab/index.html

Academic Achievement

(29)Zeng B, Chai J, Deng Z, Ye T, Chen W, Li D, Chen X, Chen M, Xu X.Functional Characterization of a Novel Lipopolysaccharide-Binding Antimicrobial and Anti-Inflammatory Peptide in Vitro and in Vivo.J Med Chem. 2018 Nov 27. doi: 10.1021/acs.jmedchem.8b01358.

(28) Huang B, Li Y, Yao Y, Shu W#, Chen M#. Dihydromyricetin from ampelopsis grossedentata protects against vascular neointimal formation via induction of TR3. European Journal of Pharmacology. Eur J Pharmacol. 2018 Nov 5;838:23-31.

(27) Qin Q, Qin J, Chen M, Li Y, Meng T, Zhou J, Liang H#, Chen Z#. Chiral platinum (II)-4-(2,3-dihydroxypropyl)- formamide oxo-aporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo. Oncotarget. 2017 Jun 28;8(37):61982-61997.

(26). Fan L, Luo J, Li X, Chen M, Shu W, Qu X#. Activation of Na⁺/H⁺ exchanger other than formation of transmembrane pore underlies the cytotoxicity of nematocyst venom from Chrysaora helvola Brandt jellyfish.Toxicon. 2017 Jul;133:162-168.

(25). Huang B., Yang F., Shu W., Chen Z.,Chen M#. Functional roles of shear stress in vascular endothelial cells. Cell Immunol Serum Biol.2017,3(1):64-67 

(24). Yang F., Shu W., Chen M#. Functional roles of protein arginine methyltransferase 5 in cardiovascular diseases. J Cell Signal. 2016,1: 123

(23). Chen M#., Qu X., Zhang Z., Wu H., Qin X., Li F., Liu Z., Tian L., Miao J.#, Shu W#. Crosstalk between Arg methylation and Ser phosphorylation modulates ASK1 activation in endothelial cells. Mol.Biol.Cell. 2016，27（8）： 1358-1366

(22). Chen M., Yi B., Zhu N., Wei X., Zhang G., Huang S., Sun J#. Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633. Cardiovasc Res. 2016, 109(1):141-50

(21).Chen M., Yi B., Sun J#. Inhibition of cardiomyocyte hypertrophy by protein arginine methyltransferase 5. J. Biol. Chem. 2014, 289(35):24325-24335

(20). Qin Q. *, Chen M. *, Yi B., Li P., You X., Yang P., Sun J#. Orphan nuclear receptor Nur77 is a novel negative regulator of ET-1 expression in vascular endothelial cells. Journal of Molecular and Cellular Cardiology. 2014 (77):20-28 (*co-first author)

(19). Chen M., Yang B., Ying W., He F., Qian X#. Annotation of non-synonymous single poly- morphisms in human liver proteome by mass spectrometry. Protein Pept Lett. 2010, 17(3):277-286

(18). Chen M.,# Wang Y., Zhao Y., Gong J., Yang Z., Qian L.# Dynamic proteomic and metabolomic analysis reveal dysfunction and subclinical injury of rat liver during restraint stress. Biochim Biophys Acta – Proteins & Proteomics. 2009, 1794(12): 1751-1765.

(17). Wang X., Gong J., Liu X., Zhan R., Kong R., Zhao Y., Wan D., Leng X., Chen M.,# Qian L.# Expression of uncoupling protein3 in mitochondria protects against stress-induced myocardial injury: a proteomic study. Cell Stress Chaperones. 2010, 15(6):771-779.

(16). Chen M., Ying W., Song Y., Liu X., Yang Bi., Wu S., Jiang Y., Cai Y., He F., Qian X#. Analysis of human liver proteome using replicate shotgun strategy. Proteomics. 2007, 7 (14): 2479-2488

(15). Jiang Y.*, Ying W.*, Wu S.*, Chen M.*., Guan W., Yang D., Song Y., Liu X., Li J., Hao Y., Sun A., Geng C., Li H., Mi W., Zhang Y., Zhang J., Chen X., Li L., Gong Y., Li T., Ma J., Li D., Yuan X., Zhang X., Xue X., Zhu Y., Qian X.#, He F#., et al. First insight into human liver proteome from PROTEOMESKY-LIVERHu 1.0, a publicly available database. J Proteome Res. 2010, 9(1): 79-94 (*co-first author）

(14). Chen M.#, Wang L., Gao X., Gong J., Qian X., Qian L. Effect of auxiliary electrospray on liquid chromatography–electrospray ionization-mass spectrometry analysis. Journal of Chinese Mass Spectrometery Society. 2009, 30(6): 321-326

(13). Chen M., Ying W., Fang Q., Sun W., He F., Qian X#. The evaluation and application of a label-free quantitative proteomic strategy based on LC-ESI-MS/MS. Progress in Biochemistry and Biophysics. 2008, 35 (4): 401-409

(12). Chen M., Ying W., Qian X#. Progress and challenge of large scale proteome express profile. Chemistry of Life. 2007, 27(1): 17-20

(11). Chen M., Shen W.#, Ruan H., Xu L. Effects of nitric oxide on root growth and its oxidative damage in wheat seeding under salt stress. Journal of Plant Physiology and Molecular Biology. 2004, 30(5): 569-576

(10). Chen M., Shen W#., Xu L. 14-3-3 Protein. Chemistry of Life. 2002, 22(5): 445-448

(9). Yan G., Zhu N., Huang S., Yi B., Shang X., Chen M., Wang N., Zhang G., Talarico JA, Tilley DG., Gao E., Sun J#. Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation. Mol Cell Biol. 2015, 35(19):3312-23

(8). Qi J., Yang P., Yi B., Huo Y., Chen M., Zhang J., Sun J#. Heat shock protein 90 inhibition by 17-DMAG attenuates abdominal aortic aneurysm formation in mice. Am J Physiol Heart Circ Physiol. 2015, 308(8):H841-52

(7). Huo Y., Yi B., Chen M., Wan N., Guo C., Sun J#. Induction of Nur77 by hyperoside inhibits vascular smooth muscle cell proliferation and neointimal formation. Biochem Pharmacol. 2014, 92(4):590-8

(6). Liu Y., Zhang J., Yi B., Chen M., Qi J., Yin Y., Lu X., Jasmin J F., Sun J#. Nur77 suppresses pulmonary artery smooth muscle cell proliferation through inhibition of the STAT3/Pim-1/NFAT pathway. Am J Respir Cell Mol Biol. 2014, 50(2):379-388

(5). Li P., Zhu N., Yi B., Wang N., Chen M., You X., Zhao X., Qin Y., Sun J#. MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation. Circ Res. 2013, 113(10):11117-1127

(4). O-Uchi J., Jhun B, Hurst S., Bisseto S., Gross P., Chen M., Kettlewell S., Park J., Oyamada H., Smith G.., Murayama T., Sheu S#. Over-expression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. AJP-Heart and Circulatory Physiology. 2013, 305(12):H1736-1751

(3). Zhou L., Ying W., Han Y., Chen M., Yan Y., Li L., Zhu Z., Zheng Z., Jia W., Yang R.#, Qian X#. A proteome reference map and virulence factors analysis of Yersinia pestis 91001. J Proteomics. 2012, 75(3):894-907

(2). Sui S., Wang J., Yang B., Song L., Zhang J., Chen M., Liu Ji., Lu Z., Cai Y., Zhu Y., He F., Qian X#. Phosphoproteome analysis of human Chang liver cell by using SCX and a complementary mass spectrometric strategy. Proteomics. 2008, 8(10): 2024-2034

(1). Wei J., Zhang Y., Chen M., Qin P., Wang J., Cai Y., Qian X#. Effect of different experimental measures in nano-scale high performance liquid chromatography-electrospray tandem mass spectrometry on protein discovery rate. Journal of Chinese Mass Spectrometry Society. 2008, 29(4): 226-230