电子邮箱：quande_wang@163.com

       办公地址：国家重点实验室2号楼503

研究方向

    1. 自由基氟化学

    2. 含氟功能分子药物化学研究

教育背景

       2015.08 至 2019.11，香港中文大学化学系，博士，导师：Gavin Chit Tsui

       2009.09 至 2012.07，山东大学药学院，硕士，导师：方浩教授

       2005.09 至 2009.07， 山西医科大学药学院，本科

工作经历

       2019.12 至今，bat365在线平台登录入口，bat365在线平台登录入口/省部共建药用资源化学与药物分子工程国家重点实验室

       2015.03 至 2015.07，云南白药集团创新研发中心

       2012.07 至 2014.11，药明康德新药开发有限公司

独立工作后论文发表情况：

1. Mingxi Chen, Yuhui Lu, Yiwen Shen, Quande Wang*. N-Trifluoroethoxy Benzotriazolium Triflate: A Readily Available Reagent for Direct Radical Trifluoroethoxylation of Alkenes. Org. Lett. 2024, 26, 9586-9591.

2. Shichao Tian, Ning Chen, Keguang Cheng*, Quande Wang*. Radical Acylfluoroalkylation of 1,3-Enynes via N-Heterocyclic Carbene/Photoredox Cooperative Catalysis. Org. Lett. 2024, 26, 4351-4355.

3. Mingxi Chen, Quande Wang*. Fluoroalkoxylating Reagents in Organic Synthesis: Recent Advances.  Eur. J. Org. Chem. 2024, e202400316 (Invited review).

4. Feng Liang, Ning Chen, Keguang Cheng,* and Quande Wang*. N-Heterocyclic Carbene and Manganese Synergistic Catalysis: A Three-Component Radical Acylmonofluoroalkylation of Alkenes. Org. Lett. 2023, 25, 8168−8172. 

5. Shichao Tian, Mingxi Chen, Yihan Tang, Keguang Cheng*, Gavin Chit Tsui*, Quande Wang*. Acylmonofluoromethylation of alkenes via dual NHC/photoredox catalysis. Org. Chem. Front. 2023, 10, 6124-6130. 

6. Yuqing Zhou, Shichao Tian, Lixin Shen, Liqiong Zhang, Jingjing Liu, Weibin Mo*, Quande Wang*, Keguang Cheng*. Design, synthesis and in vitro antitumor activity of 17β-estradiol-amino acid derivatives. Arab. J. Chem. 2024, 17, 105539.

7. Liqiong Zhang, Li Sun, Yuqing Zhou, Jingjing Liu, Quande Wang*, Weibin Mo*, Keguang Cheng*. Pentacyclic triterpene-amino acid derivatives induced apoptosis and autophagy in tumor cells, affected the JNK and PI3K/AKT/mTOR pathway. Bioorg. Med. Chem. 2023, 94, 117478. 

8. Shaoting Chen, Yuxiang Zheng, Benji Liang, Yudong Yin, Jian Yao, Quande Wang*, Yanghan Liu*, Nouri Neamati*. The application of PROTAC in HDAC. Eur. J. Med. Chem. 2023, 260, 115746. 

9. Yudong Yin, Li Sun, Lixin Sheng, Liqiong Zhang, Jingjing Liu, Xiaoan Wen, Weibin Mo, Quande Wang*, Keguang Cheng*. (4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7. Chem-Bio. Interact. 2023, 369, 110286.

10. Kun She, Feng Liang, Shichao Tian, Hengshan Wang*, Gavin Chit Tsui*, Quande Wang*. Organocatalytic Three-Component Acyldifluoromethylation of Vinylarenes via N-Heterocyclic Carbene-Catalyzed Radical Relay. Org. Lett. 2022, 24, 4840−4844.