联系方式
办公电话：(0773)2535678
电子邮箱：zhaoshulin001@163.com
基本介绍
赵书林，博士，教授。湖南大学获学士学位，四川大学获博士学位，美国杰克逊州立大学访问学者（1999-2001年），俄罗斯莫斯科大学化学系合作研究（2013-2015年；2021-2022年）。2012-2016年任bat365在线平台登录入口院长。2011至今任bat365在线平台登录入口学术委员会主任，二级教授，博士生导师。是中国化学会有机分析专业委员会委员，曾担任国家自然科学基金委员会化学部专家评审组成员，国家自然科学基金重点项目、科学仪器专项、杰出青年基金、优秀青年基金项目评审和结题验收专家。在Science Advances, Chemical Science, AnalyticalChemistry, Chem.Commun, Chemical Engineering Journal, Biosensors and Bioelectronics, AdvancedHealthcare Materials, ACS Appl. Mater. Interfaces, 中国科学-化学，等国内外学术期刊上发表学术论文400余篇，并被SCI引用8600余次，H指数47；获国家授权发明专利15项。参写中英文专著5部。负责制定国家标准2项。科研成果获广西自然科学奖一等奖3项，二等奖2项，三等奖1项。广西科技进步奖二等奖1项，三等奖1项。
研究方向
1、单细胞分析新技术
2、生物传感新方法
3、生物成像新技术
1）光声成像探针的设计合成及应用
2）荧光成像探针的设计合成及应用
4、诊疗一体化纳米体系的设计和构建
5、药物靶向转运体系的设计和构建
讲授课程
仪器分析；分析化学前沿；学术规范与科技写作；现代仪器分析实验
主要代表性论文：
1. Shulong Wang,Liangliang Zhang*, Jingjin Zhao, Min He, Yong Huang, Shulin Zhao*. A tumor microenvironment–induced absorption red-shifted polymernanoparticle for simultaneously activated photoacoustic imaging and photothermaltherapy. Science Advances, 2021, 7, eabe3588.（TOP期刊）
2. Chaobang Zhang, Zhidong Qiu, LiangliangZhang,* Qiufang Pang, Zhengmin Yang, Jiang-Ke Qin, Hong Liang, Shulin Zhao.* Design and synthesisof a ratiometric photoacoustic imaging probe activated by selenol for visualmonitoring of pathological progression of autoimmune hepatitis. Chemical Science, 2021,12, 4883–4888.（TOP期刊）
3. Jingjin Zhao,‡ Mengbing Zou,‡Mengjiao Huang, Liangliang Zhang, Keqin Yang, Shulin Zhao,* Yi-Ming Liu.*Amultifunctional nanoprobe for targeting tumors and mitochondria with singletoxygen generation and monitoring mitochondrion pH changes in cancer cells byratiometric fluorescence imaging Latexin deficiency attenuatesadipocyte differentiation and protects mice against obesity and metabolicdisorders induced by high-fat diet.Chemical Science, 2020,11, 3636–3643.（TOP期刊）
4. Yulong Bai, Jingjin Zhao, LiangliangZhang*, Shulong Wang, Jing Hua, Shulin Zhao*,Hong Liang*. A Smart Near-Infrared Carbon Dot-Metal Organic Framework Assemblies forTumor Microenvironment-Activated Cancer Imaging and Chemodynamic-PhotothermalCombined Therapy, Adv. Healthcare Mater., 2022,2102759.（TOP期刊）
5. Shulong Wang, Jingjin Zhao, LiangliangZhang*, Chaobang Zhang, Zhidong Qiu, ShulinZhao*. Yong Huang, Hong Liang*.A Unique Multifunctional Nanoenzyme Tailored for Triggering TumorMicroenvironment Activated NIR-II Photoacoustic Imaging and Chemodynamic/PhotothermalCombined Therapy. Adv. Healthcare Mater., 2021,2102073.（TOP期刊）
6. Yulong Bai, Jingjin Zhao,* Shulong Wang,Tianran Lin, Fanggui Ye, Shulin Zhao*. Carbon Dots withAbsorption Red-Shifting for Two-Photon Fluorescence Imaging of Tumor Tissue pHand Synergistic Phototherapy. ACS Appl. Mater. Interfaces, 2021, 13, 35365−35375.
7. Bingfang Shi, Yubin Su, LiangliangZhang,* Mengjiao Huang, Rongjun Liu, Shulin Zhao.* Nitrogen and PhosphorusCo-Doped Carbon Nanodots as a Novel Fluorescent Probe for Highly SensitiveDetection of Fe3+ in Human Serum and Living Cells.ACSAppl. Mater. Interfaces, 2016, 8,10717−10725. （TOP期刊）
8. Zhidong Qiu,Chaobang Zhang, Liangliang Zhang,* Shulong Wang, Shengqiang Hu, Shulin Zhao.*Precise in VivoInflammation Imaging in the NIR-II Window Using 1065 nm Photoacoustic Probe forin Situ Visual Monitoring of Pathological Processes Related to Hepatitis. ACSSens., 2022,7, 641−648.（TOP期刊）
9. ShengyuChen, Jingjin Zhao,* Ivan Yu Sakharov, Jiayao Xu, Chunhuan Xu, Shulin Zhao.* An ultrasensitivemultivariate signal amplification strategy based on microchip platform tailoredfor simultaneous quantification of multiple microRNAs in single cell, Biosensors and Bioelectronics, 2022, 203,114053. （TOP期刊）
10. Chunhuan Xu, Jingjin Zhao,* ShengyuChen, Ivan Yu Sakharov, Shengqiang Hu, ShulinZhao.* An ultrasensitive bunge bedstraw herb type DNA machine for absolutequantification of mRNA in single cell.Biosensors and Bioelectronics, 2022, 217,114702.（TOP期刊）
11. BingfangShi, YubinSu, Liangliang Zhang, RongjunLiu, MengjiaoHuang, Shulin Zhao.* Nitrogen-rich functional groupscarbon nanoparticles based fluorescent pH sensor with broad-range responding forenvironmental and live cells applications.Biosensors and Bioelectronics, 2016, 82,233–239.（TOP期刊）
12. LiyunLin, Yuefang Hu, Liangliang Zhang*, Yong Huang, Shulin Zhao*. Photoluminescence light-up detection of zinc ion andimaging in living cells based on the aggregation induced emission enhancementof glutathione-capped copper nanoclusters. Biosensors and Bioelectronics, 2017, 94, 523–529.
13. Guoxing Qin, Shulin Zhao,* Yong Huang, Jing Jiang, Yi-Ming Liu*. A sensitive goldnanoparticles sensing platform based on resonance energy transfer forchemiluminescence light on detection of biomolecules.Biosensors and Bioelectronics, 2013, 46, 119–123.（TOP期刊）
14. ShulongWang, Liangliang Zhang,* Yanni Luo, Yulong Bai, Yong Huang, Shulin Zhao*. A Circular Dichroism and Photoacoustic Dual-Mode Probe for DetectionIn Vitro and Imaging In Vivo of Hydroxyl Radicals.Anal. Chem., 2022, 94, 2453−2464.（TOP期刊）
15. Chaobang Zhang, Zhidong Qiu,Liangliang Zhang, Shulong Wang, ShulinZhao,* Qiufang Pang, Hong Liang*. Mitochondria-Targeted Fluorescence/ PhotoacousticDual-Modality Imaging Probe Tailored for Visual Precise Diagnosis ofDrug-Induced Liver Injury. Anal. Chem., 2022, 94, 6251−6260.（TOP期刊）
16. Shengyu Chen, Jingjin Zhao, Chunhuan Xu,Ivan Yu. Sakharov, Shulin Zhao*. Absolute Quantification of MicroRNAs in a Single Cell with ChemiluminescenceDetection Based on Rolling Circle Amplification on a Microchip Platform. Anal. Chem., 2021, 93, 9218−9225.（TOP期刊）
17. Chaobang Zhang,# RongkangGao,# Liangliang Zhang, Chengbo Liu,* Zhengmin Yang, Shulin Zhao*. Design and Synthesis of aRatiometric Photoacoustic Probe for In Situ Imaging of Zinc Ions in Deep TissueIn Vivo. Anal. Chem., 2020, 92, 6382−6390. （TOP期刊）
18. Kun Hu, Yuanxia Lv, Fanggui Ye,* Tao Chen, Shulin Zhao*. Boric-Acid-Functionalized Covalent Organic Framework for Specific Enrichment and DirectDetection of cis-Diol-Containing Compounds by Matrix-Assisted LaserDesorption/Ionization Time-of-Flight Mass Spectrometry. Anal. Chem., 2019,91, 6353−6362. （TOP期刊）
19. Rongjun Liu, Liangliang Zhang,* YunyunChen, Zirong Huang, Yong Huang, ShulinZhao*. Design of a New Near-InfraredRatiometric Fluorescent Nanoprobe for Real-Time Imaging of Superoxide Anionsand Hydroxyl Radicals in Live Cells and in Situ Tracing of the InflammationProcess in Vivo. Anal. Chem., 2018, 90, 4452−4460. （TOP期刊）
20. Dongxia Chen, Jingjin Zhao, Liangliang Zhang,* RongjunLiu, Yong Huang, Chuanqing Lan, ShulinZhao*.Capsicum-DerivedBiomass Quantum Dots Coupled with Alizarin Red S as an Inner-Filter-MediatedIlluminant Nanosystem for Imaging of Intracellular Calcium Ions. Anal. Chem., 2018, 90, 13059−13064.（TOP期刊）
21. Jingjin Zhao,# Mengjiao Huang,#Liangliang Zhang,* Mengbing Zou, Dongxia Chen, Yong Huang, Shulin Zhao*. Unique Approach To Develop Carbon Dot-BasedNanohybrid Near-Infrared Ratiometric Fluorescent Sensor for the Detection ofMercury Ions. Anal. Chem., 2017, 89, 8044−8049. （TOP期刊）
22. Shengyu Chen, Jingjin Zhao,* Bingfang Shi,Chunhuan Xu, Shulin Zhao*.Anultrasensitive chemiluminescence strategy based on a microchip platform fortelomerase detection at a single-cell level. Chem. Commun., 2021, 57, 3095–3098. （TOP期刊）
23. Chunhuan Xu, Shengyu Chen, Jingjin Zhao,*Xiaoshu Luo, Shulin Zhao*. ADNAzyme-mediated target-initiated rolling circle amplification strategy basedon a microchip platform for the detection of apurinic/apyrimidinic endonuclease1 at the single-cell level. Chem. Commun., 2021, 57, 11017–11020.（TOP期刊）
24. Shengyu Chen, Jingjin Zhao, Xing Yang, Shulin Zhao*, Yi-Ming Liu*. A novelintracellular signal amplification strategy for the quantification of ATP insingle cells by microchip electrophoresis with laser-induced fluorescencedetection. Chem. Commun., 2020, 56, 6579–6582.（TOP期刊）
25. Liyun Lin, Jingjin Zhao, * Liangliang Zhang, YongHuang, Fanggui Ye, Shulin Zhao*. Real-time tracing the changes in theintracellular pH value during apoptosis by near-infrared ratiometricfluorescence imaging. Chem.Commun., 2018, 54,9071–9074.（TOP期刊）
近十年承担的科研项目
（1）国家自然科学基金项目(科学仪器专项)：一种多检测模式多功能的微流控芯片单细胞分析仪的研制（300万元）(2014.1-2017.12)
（2）广西八桂学者项目：生命分析化学（500万元） (2017.1-2022.13)
（3）国家自然科学基金(面上项目):近红外和上转换发光掺杂碳基量子点的制备及在生物传感和成像中的应用（78万元）（2016.1-2019.12）
（4）国家自然科学基金 (面上项目): 用于活体和细胞内活性小分子比率荧光成像的纳米探针研究（65万元） (2019.1-2022.12)
（5）国家自然科学基金 (面上项目): 体内活性小分子激活的近红外二区光声成像纳米探针的研制及应用（60万元）（2022.1-2025.12）
（6）广西自然科学基金（重点项目）：功能化碳基量子点探针的研制及在生物传感和细胞成像中的应用（30万元）（2015.9-2018.8）
（7）国家自然科学基金(国际合作交流项目): 肿瘤相关miRNAs的单细胞分析和比率荧光成像（15万元） (2021.1-2022.12)
(8) 国家自然科学基金(面上项目): 基于化学发光共振能量转移检测的微流控芯片免疫和核酸分析新方法研究（68万元） (2012.1-2015.12)主要荣誉称号
广西八桂学者（2016年）
广西优秀专家（2010年）
广西八桂名师（2009年）
广西先进工作者（2010年）
享受国务院政府特殊津贴专家（2016年）